Further into the forest there is more firewood value. The meaning of the proverb: “The further into the forest, the more firewood. The deeper the forest, the more firewood.

Chapter 18 1. Dispute among the disciples about who is greatest in the kingdom of heaven 1. At that time the disciples came to Jesus and said, “Who is greatest in the kingdom of heaven?” (Mark 9:33, 34; Luke 9:46, 47). The parallel story of the weather forecasters (before Matt. 17:23; Mark 9:32; Luke 9:45) was interrupted by an insertion in Matt. 17:24-27 story about payment

The thin crescent moon shone faintly over the forest. The hundred-year-old trees, as if talking to each other, quietly rustled their leaves. Somewhere in the distance a mournful howl was heard. And under the silver-black cover of night...
Oops, sorry, this is not the same story at all!..
And in our story, it was early evening, the glorious city of Tokyo was noisy, living its hectic life, and Detective L was searching Light Yagami’s room.
Or rather, there was no need to search - the Notebook, which had once again escaped from its hiding place, was having fun with a porn magazine right on the table. L leaned over the table, putting his thumb in his mouth and watching what was happening with great interest. The pages intertwined and unraveled, squeezed and rubbed against each other... And at times it even seemed that quiet moans were heard in the air, sounding somewhere on the verge of hearing...
When this paper disgrace was over, L tore the Notebook away from the indignantly slammed cover of the porn magazine and began to look at it. I read the rules, looked through the names written in the Notebook... in a word, I found everything that confirmed the hypothesis: Light Yagami - Kira.
“So, you are still Kira, Light...” the detective said quietly, sighing. - It's a pity. You are damn smart, you could achieve a lot... But you chose this path in vain.
And the next second, he dropped the Notebook back on the table, where she had begun the second, or maybe the twenty-second round with the porn magazine, and dived behind the curtain, because steps and Light’s voice were heard in the corridor:
-Ryuk, damn you, stop pawing me! Oh, Ryuk... Well, let’s at least go into the room!
-Stop it? - unfamiliar voice. - Yes, I haven’t started yet. But I'll start right now! Just don't forget to lock the door...
The door opened, then closed, the latch on the door turned... Light's steps and his uneven breathing were heard, which soon turned into quiet groans... The detective was tormented by curiosity with terrible force. Who is Ryuk? Probably the god of death, who, according to the rules, should follow the owner of the Notebook... And what the hell are he and Light doing there?!
There was not a single hole in the thick curtain, to Ryuzaki’s deepest disappointment. In the end, he could not stand it and looked out from behind the curtain. The sight that met his eyes made L's jaw drop, and his pants became noticeably tight. Light, wearing only trousers and with his hands tied behind his back, squirmed, moaning softly, in the arms of a tall black monster who, apparently, was Ryuk. Ryuk's clawed hands slid over the young man's body, and here and there pink scratches remained on the delicate skin. And then the god of death squeezed Light’s buttocks and lifted him off the floor, pressing him tightly into his groin, making it clear how much he wanted the guy. This made Light groan, muffled and low.
-Not only are you Kira, you’re also a pervert! – the detective couldn’t stand it.
-Oops! Yes, we have a guest! – Ryuk was delighted, anticipating that now it would become even more fun.
He and Light simultaneously turned their heads towards the detective.
-L, what the hell... – Light began, but Ryuk interrupted him:
“You’d think you’re absolutely normal, and your pants aren’t bursting now!” he snorted, turning to Ryuzaki. - Anyway, do you want to join?
L froze for a moment, deciding whether to accept such an obscene offer, and Light successfully filled the pause that arose.
-Are you two going to beat me up? – he asked, rounding his eyes.
This prospect scared Kira a little, but at the same time excited her.
- Just like the two of us! - L responded, licking his lips and taking off his oversized sweater, and then took hold of his pants.
While the detective was undressing, Ryuk managed to drag Light onto the bed and rummage around for a jar of lubricant in the nightstand. The jar opened with a slight pop, and the next second a naked Ryuzaki joined Light and Ryuk on the bed.
Light groaned strangledly when they began to caress him with four hands. Ryuk squeezed almost to the point of pain, sometimes scratched, and L was gentle, his palms fluttered over the body like warm moths. This contrast of caresses made my head spin, and my penis acquired diamond hardness.
“How sensitive you are... Kirochka...” the detective whispered in Light’s ear, and then gently licked the pink ear. – A little more and you’ll cum right in your pants, right?..
- Figurines for him! – Ryuk grinned. “Cumming in your pants is bad manners, do you hear, Light?” – The God of Death winked at L and said: “I’ve got something here...
He rummaged in his pockets and pulled out a large black vibrator, a ball gag and a cock ring.
-Wow! – Ryuzaki whistled. - I thought you’d also get a whip...
-No... If you want to be sadistic, I’ll make do with my claws... – Ryuk showed off his impressive claws, and L nodded respectfully.
-Sadists!.. – Light exhaled. - Concerned maniacs... I'm afraid of you! Will I even be alive after your entertainment?
“Shh... don’t be afraid...” L whispered affectionately in his ear. - You will be alive and completely healthy. And you will also enjoy...
“Yeah, he’s afraid!..” the God of Death snorted, pulling off Light’s pants along with his underpants. “You may be afraid, but your dick isn’t even a little afraid.” What a price! – with these words he put a ring on Light’s penis. - All is ready! – Ryuk slapped the guy on the ass. “Now you won’t cum until we allow you to.”
Another portion of sweet caresses that made Light squirm and moan, and Ryuk reached for a jar of lube. The God of Death froze in thought, holding a jar in one hand and scratching the back of his head with the other hand. Usually Light lubricated himself, because, given the by no means small size of Ryuuk’s love machine, doing without lubrication and preparation would be simply stupid. But now Light's hands are tied. And Ryuk will definitely rip his entire butt off with his claws...
L, quickly realizing what the problem was, took the lubricant from Ryuk, and his thin fingers slid along Light’s butt, climbed into the hollow between his buttocks and felt a neat hole.
Kira moaned sweetly, resting his forehead on the detective's shoulder while he stretched him with his deft fingers. And L gently licked and bit Light's ear. The detective always had a weakness for such pretty pink ears...
But soon Ryuk got tired of waiting, he pushed Ryuzaki away, pulled his penis out of his pants, lubricated it and thrust it into Light - sharply, with one powerful push, as he always did, except for the first few times, when he was still careful... Light gasped. Ryuzaki hugged him by the shoulders, whispering some kind of affectionate nonsense in his ear, and looked angrily at Ryuk. He snorted mockingly, but decided that maybe he really should be a little more gentle with Light...
And then a strong hand forced Light to bend forward. Ryuk, holding Light's hip with one hand and his tied hands with the other, began to move in him, not too fast yet. L's member was right in front of her face, and the detective gently but persistently pressed the back of Kira's head, showing what he wanted. A gentle voice, slightly hoarse with desire, sounded from above:
-Just don’t let your teeth loose, okay?
And Light opened his mouth, letting the head in, licking and sucking, slowly swallowing the penis deeper... Hearing Ryuzaki moaning with pleasure...
“They have me like a whore!..” - the only coherent thought that the mind foggy with passion could generate.
What was happening was humiliating for Light, but at the same time damn exciting. Two members burst into his writhing body, and he either leaned back, trying to let Ryuk into himself deeper, then forward, swallowing L’s member to the very base, and his mind had long since turned off. He probably would have already come, but the ring on his penis did not allow this, and the arousal was already becoming painful.
No one could say exactly how long it lasted - everyone lost their sense of time. With a muffled groan, he reached peak L, spilling into Light's mouth... Almost simultaneously with him, Ryuk came... Light, who was still in an excited and dissatisfied state because of the ring on his penis, let out a plaintive moan, more like a whine . They fucked him in the most brazen manner and left him unsatisfied, curled up on the bed like a “zyu” and with his nose buried in the pillow...
Then someone’s hand spread his buttocks, and something finely vibrating began to push into Light’s ass. Deeper and deeper... Then the ring was removed from the penis. Light moaned desperately - according to the law of meanness, he just needed a little bit to cum. He unstuck his nose from the pillow and stood on the bed on his knees, arching his back with all his might and twisting his bound hands, reaching for the vibrator. He grabbed it with his fingers, pulled it out about halfway, again pushed it into the depths of his body... More... And more... And he came, falling exhausted onto the bed and plunging into semi-oblivion...
He vaguely felt how the vibrator was pulled out of him, how his hands were untied... Ryuzaki sat down next to him and began to rub Light’s wrists, kissing his fluttering eyelids. Kira purred quietly, he didn’t even care that the gentle caresses were being given to him by none other than L, who swore in front of the whole world that he would put him in the electric chair. And it’s unlikely that today will prevent the detective from doing this. But despite this, Light liked L more than Ryuk. The God of Death recently seems to have begun to consider Kira his personal whore, who can be had as he pleases. And you can’t run away from him anywhere and you can’t hide anywhere...
And now... Ryuk pushed Ryuzaki aside, and tied Light by the hands to the bed. The latter's protest was immediately muffled by a ball gag. A portion of caresses bordering on roughness, a few more scratches on the delicate skin... Light almost hated himself for being excited by this. Ryuk grinned, running his hand over Light's penis, and turned the guy over in his favorite position - on all fours. A little lubricant on the penis - and the God of Death entered Light: abruptly, without ceremony, without trying to be careful... A groan muffled by the gag was heard in the air. Light arched, involuntarily leaning back. Everything has disappeared: the thoughts that this is wrong and immoral, the feeling of self-hatred because he, accustomed to being in charge in everything, puts himself up so obediently, and even gets pleasure from it... All that remains is pleasure. Painful - from the penis, plunging into his body with powerful thrusts, stretching it to the limit, so that it seemed that the tender flesh was about to tear; sharp, with a hint of slight fear because Ryuk, caressing his penis with his hand, could touch it with his claws... Pleasure twisted inside in a tight spiral, forcing him to squirm and moan, leaning towards the movements... With another, especially loud moan, Light came.
Ryuk made several more powerful movements, bursting into the body relaxed after an orgasm, squeezing Light’s hips so tightly that his claws dug into the skin until he bled, and also reached the peak. The God of Death let go of the guy, and he fell exhausted onto the bed.
Light barely had time to come to his senses a little when he was turned over on his back, and now L was taking care of him. The detective acted more affectionately, gently kissed, stroked, even when he bit lightly, it was only sweet and nothing else. Light purred softly with pleasure. Hot lips covered his neck with kisses, explored his collarbones, went lower, licking and sucking his nipples... And lower - the tongue teased the cavity of his navel a little... And even lower - Light's penis was plunged into moist silky warmth...
Very soon Kira was ready for the next round. He himself spread his legs, inviting. L did not skimp on lubrication and entered gently and smoothly. Not the slightest discomfort, just pleasure. The head is thrown back, the lover's tongue flutters along the exposed neck, the penis rubs sweetly inside, constantly touching the prostate, and his own burning organ is captured by gentle fingers...
I wanted to run my hands through my disheveled black hair, but my hands were tied. I wanted to moan out loud, but the gag muffled the moans. But it's still good. Too, too good... With another gag-muffled moan, Light cums and feels Ryuzaki cum with him.
Then L finally untied Light’s hands. And he pulled out the gag to press a slow, soft kiss to his lips. Light answered lazily, relaxing in the warm embrace. And he tried not to think about the fact that Ryuk would definitely not have enough and he would, without ceremony, fuck Light again. Kira wasn't sure he had enough strength for another round. Although from L’s leisurely caresses his penis began to rise again...
But Ryuk had no time for Light and Ryuzaki now - the God of Death found... an apple in one of his pockets! And now he stood with this apple in the middle of the room, wondering how it was not immediately devoured, but ended up in his pocket and lay there for an unknown amount of time.
Meanwhile, L again pressed Kira to the bed, spreading his legs with his knee. He did not resist - the detective finally brought him to the required condition. And again Light was gently and sweetly taken, only now his arousal was not so strong, and his overworked hole began to ache... But thanks to the kisses and caresses that L generously gave him, the arousal was stronger than the discomfort.
But Ryuzaki still finished before Light. The detective began to lay a trail of kisses down, intending to take his lover into his mouth, but Ryuk interfered. The sight of Light under L turned on the God of Death, and now, seeing that Light was still hard, he pushed the detective away and sat on the edge of the bed, easily lifting Light and impaling him on his penis. Ryuzaki, who was watching this picture, widened his eyes in shock - he did not think that Ryuk was so physically strong. Light, already almost completely fucked, only moaned quietly, throwing his head back on Ryuk's shoulder when he lifted him up and pushed him back onto his dick. The detective reached out to him, caressing the aroused flesh with one hand, lightly pinching the nipples with the other. A little more - and Light came along with Ryuk.
“In my opinion, we’re too cool with him...” said Ryuzaki, together with the God of Death, arranging the fucked and sleepy Light on the bed.
“Perhaps...” Ryuk chuckled. “Light, of course, is a sweet piece of candy, and he loves this thing, no matter what he says... But I can pick him up alone, right, Light?” – In response, the God of Death received only an inaudible grumbling. - And even more so together. But, to be honest, I wouldn’t refuse it again...
Light rose above the bed and, looking at Ryuk with a dull gaze, muttered:
-It’s better to kill me right away... I can’t do it anymore today. Or that one,” a weak nod towards the detective. - Persuade...
In general, Light was settled on the bed and even carefully covered with a blanket. And then this preoccupied God of Death persuaded L to “one more time.” Light sleepily watched from the bed as the two pretended to be 69. Standing. Moreover, Ryuk was floating in the air upside down. The spectacle was exciting and very entertaining; at any other time Light would have gotten hard, but now his penis only twitched sluggishly.
“Concerned maniacs...” - Kira thought lazily. - “They really fucked me today... Especially Ryuk, he’s always fucking trying, he’s a lover of hard sex, damn! How many times have I already told him: be careful, people are fragile creatures, you can’t do this to them. It's all useless... Hmm, I didn't think that L would be able to take such a big dick into his mouth as Ryuk's. Apparently, he practiced well on lollipops...”
He had almost passed out when Ryuzaki lay down next to him.
“I should take a shower...” he said.
“Laziness,” Light answered him. - And suddenly someone sees us...
Ryuk looked at the guys and decided to do a good deed. First, he flew into the corridor and made sure that there was no one there, then he returned and, throwing Kira and L on his shoulders, dragged them into the bathroom. Once there, the God of Death looked into the mirror and chuckled: the mirror did not reflect him, only two guys hanging in the air with their butts up.
“Enjoy,” he unloaded his burden into the bath and opened the warm water. - And I went.
L made the water a little hotter, then the guys didn’t move for a while. The detective sat with his back leaning against the edge of the bathtub, and Light rested his head on his chest. Ryuzaki's slender fingers easily ran through his red hair.
“You’re petting me...” Light said quietly. – You caress... And then just as affectionately you’ll sit me in the electric chair, right?
“Maybe yes, maybe not...” L answered calmly.
Light raised his head and stared at him in bewilderment, even all the drowsiness disappeared.
“You see, Light...” the detective began. “Your brain is too valuable a thing to be thrown away like that.” So either you agree to give me the Death Note and work with me, or... I actually put you in the electric chair.
“Hmm... Well, considering that I still want to live, I think I’ll agree,” Light decided that now it’s better to accept L’s offer to work together, and then see what comes of it. Of course, the detective would not trust him 100% and would keep an eye on him, but Light was sure that if he wanted to, he would sooner or later find a loophole.
Having somehow rinsed off, the guys crept into the room, lay down on the bed and fell asleep almost instantly.

Light, get up immediately! – Father’s voice from behind the door. – Light!!!
-Dad?.. – sleepily.
-Mother has already tried to wake you up twice, but she didn’t achieve anything and called me. And I won't leave until I wake you up! It's time for you to go to university! Either get up or I'll break down the door!!! And why the hell did you lock it?!
“Damn university...” Light mutters sleepily, tries to sit up in bed and groans: after yesterday’s sex marathon, his butt hurts, one might even say it hurts like hell. Light falls back onto the pillow and makes a thoughtful conclusion: - So, I didn’t dream...
He squints his eyes to the side and sees L next to him: he is sleeping, as they say, without his hind legs, curled up in a ball, quietly snoring and sucking his thumb. Light unceremoniously pushed him aside and asked:
-What did you say yesterday about the electric chair and two options?
L winced with displeasure and said:
-I said that I won’t send you to execution if you agree to work with me. But if you poke me in the ribs with your elbow like that one more time, I’ll spit on your consent and sit you on the damn chair, understand?!
-Understood...
-Light! Light!!! – Soichiro Yagami yelled from behind the door. - Get up, damn you!..
- The devil tore me yesterday... - under his breath. Then, louder: “I won’t get up!” I now have a new interesting job, and I can give a damn about university. And now I will sleep!!!
And while Soichiro was scratching his head and trying to figure out what Light was talking about, he successfully passed out...

Every solution creates new problems (Murphy's law)

Analogues of the expression “further into the forest, more firewood”

• The further into the argument, the more words
• Life is not a field to live
• Without knowing grief, you will not know joy
• God gave the day, He will also give food
• If you don't catch a crucian carp, you'll catch a pike
• How many days does God have ahead, so many misfortunes
• Live forever, hope forever
• What will happen will happen, you can’t escape it
• Further out to sea - more sorrow
• Where there is fire, there is smoke

Applications of proverbs in literature

— « When you finally go upstairs,” Apollo continued, “it turns out that you will have a duel with a giant spider - and the further you go into the forest, the thicker the spiders become.”"(Victor Pelevin "Batman Apollo")
— « While there was still talk about tobacco, about a bottle of vodka, until then, one way or another, they could help him, but the further into the forest - the more firewood, and Kornev and Kartashev were lost, seeing that, in fact, there was no end to Konon’s demands will"(N. G. Garin-Mikhailovsky “Gymnasium students”)
— « The further into the forest, the more firewood: all Arkov residents owe, their debt grows with each new crop, with each extra head of livestock, and for some it already extends to an unpaid figure - two or even three hundred rubles per capita"(A.P. Chekhov "Sakhalin Island")
— « Anninka became convinced that the further into the forest, the more firewood there was, and she began to finally say goodbye"(M. E. Saltykov-Shchedrin “Gentlemen Golovlevs”)

Since ancient times, people have learned to notice certain relationships between various phenomena and analyze them. And although they did not mean much then, they found their expression in various proverbs, sayings and sayings.

What is the role of folk wisdom in people's lives

Wise thoughts and advice for all occasions, which are contained in proverbs, accompany us throughout our lives. And despite the fact that some proverbs are hundreds of years old, they will always be relevant, because the basic laws of life will never change. There are a lot of wise sayings, for example: “The further into the forest, the more firewood”, “It looks smooth, but is not sweet in the tooth”, “Praise is ruin for a good man”, “If you wait, you will see, if you wait, you will hear”, etc. All of them briefly and clearly characterize certain actions, relationships, phenomena, and give important life advice.

“The further into the forest, the more firewood.” Meaning of the proverb

Even in ancient times, without even knowing how to count, people noticed certain patterns. The more game they get while hunting, the longer the tribe will not suffer from hunger, the brighter and longer the fire burns, the hotter it will be in the cave, etc. The further into the forest, the more firewood - this is also a fact. At the edge of the forest, as a rule, everything has already been collected, but in the deep thicket, where no human has ever set foot, there is apparently no firewood. However, this saying has a much deeper meaning. Forest and firewood do not need to be taken literally; people simply expressed certain patterns that occur in our lives through the interconnection of these concepts.

In the proverb “the further into the forest, the more firewood,” the meaning is this: the deeper you delve into any business or undertaking, the more “pitfalls” come to the surface. This expression can be applied to many concepts and situations. For example, the deeper you begin to study a question, the more details you learn about it. Or the longer you communicate with a person, the better you understand the characteristics of his character.

In what situations is the proverb “The further into the forest, the more firewood” most often used?

Despite the fact that the meaning of the proverb allows it to be used in many situations, it is most often used when we are talking about the occurrence of unforeseen difficulties and complications in any undertaking. It’s not for nothing that the proverb refers specifically to firewood. Everyone knows that the expression “to mess things up” means “to make a mistake by acting rashly,” that is, it is interpreted in a disapproving way.

This proverb can be applied not only in relation to a specific task that has been started. “The further into the forest, the more firewood” - this can be said in relation to a person who, for example, constantly deceives others, and lies draw him into a vicious circle, giving rise to more and more new lies. Or, for example, someone wants to climb the career ladder and is ready to do anything for this. If in order to achieve his goal he plays a dishonest game, then the higher he climbs the “steps”, the more unseemly acts he has to commit.

Conclusion

Folk wisdom, embedded in proverbs and sayings, briefly and succinctly characterizes all aspects of life - relationships between people, attitudes towards nature, human weaknesses and other aspects. All the proverbs and wise sayings are a real treasure that people have been collecting bit by bit for centuries and passing on to future generations. By proverbs and sayings one can judge the values ​​that are inherent in different cultures. It is precisely such statements that contain a vision of the world as a whole and in various private life situations. It is difficult to overestimate the importance and role of proverbs and sayings in the life of society. They are the spiritual heritage of our ancestors, which we must honor and protect.

The traditional role of the family of small interfering RNAs (siRNAs), small RNA molecules that do not code for proteins, is considered to be the repression of gene activity and, in particular, protein synthesis. However, a new study has shown (for the umpteenth time!) that the functions of one of the groups of these molecules - microRNAs - are much broader: in certain cases they can stimulate translation rather than block it.

In the last ten to fifteen years, the basic dogma of molecular biology (“DNA → RNA → protein”) has been significantly weakened and expanded due to the fact that a great many molecular mechanisms have been discovered that stand out from this harmonious concept. The discoveries associated with short, non-protein-coding RNA molecules were revolutionary: this included the famous phenomenon of RNA interference (noted by the Nobel Prize shortly after its discovery) and other mechanisms of RNA-dependent gene repression. One of the varieties of short RNAs - microRNAs (miRNAs; miRNA) is actively involved in the processes of individual development of the body, including temporal control, death, cell proliferation and differentiation, and embryonic organ formation. They fine-tune gene expression at the post-transcriptional level, thereby adding another layer of complexity to the sophisticated mechanism of intracellular regulation. Originally discovered in a "laboratory" nematode C. elegans, miRNAs were then discovered in many plants and animals, and more recently in single-celled organisms.

Previously, it was believed that short RNAs are used by cells in the process of RNA interference for the specific degradation of unnecessary or harmful RNAs - in particular, this is how a cell can destroy foreign genetic material of viruses, related retrotransposons and other mobile elements, as well as RNA formed as a result of transcription genomic repeat sequences. Therefore, it was logical to assume that short RNAs serve as a kind of prototype of the “immune system” inside the cell. As our understanding of the participants and mechanisms of RNA-dependent gene repression developed, more and more interesting features were discovered, and a rich variety of ways of implementing this repression existing in nature was revealed.

The mechanism of action of most miRNAs is in many ways similar to RNA interference - a short (21–25 bases) single-stranded RNA as part of a protein complex (the key component of which is a protein of the Argonaute) bind with high specificity to the complementary region in the 3′-untranslated region (3′-UTR) of the target mRNA. In plants whose miRNAs are completely complementary to a segment of the target mRNA, binding leads to cleavage of the mRNA by the protein Argonaute right in the middle of the miRNA–mRNA duplex - a situation closest to “classical” RNA interference. In animals, miRNAs are not completely complementary to their target, and the result of binding is different. For a long time it was believed that binding leads to translational suppression (the mechanism of which still remains a mystery) and does not cause any noticeable degradation of the target mRNA. However, it was later convincingly demonstrated that for most miRNAs this is not the case - proteins forming a complex with miRNAs stimulate the degradation of target mRNA, attracting enzymes that remove the cap at the 5′ end and shorten the poly(A) tail at the 3′ end. end of the mRNA. (This is where the degradation of mRNAs that have served their purpose usually begins.) Surprisingly, it is still not entirely clear whether the suppression of translation is a cause or a consequence of the onset of mRNA degradation.

Meanwhile, life once again demonstrates its reluctance to fit into any clear-cut schemes: in the laboratory of Joan Steitz ( Joan Steitz) it was found that siRNAs can effectively suppress translation by binding not only to the 3′ untranslated region of mRNA, but also to the 5′ UTR. And recently in the magazine Science another article from this successful laboratory appeared. It says that under certain conditions (reminiscent of cells going into “hibernation” when they are cultivated in the absence of serum in a nutrient medium), the interaction of miRNA and target mRNA leads to a strictly opposite effect - enhancing synthesis target protein. This was shown for the mRNA of one of the cytokines, tumor necrosis factor α (TNF-α), and the miRNA miR369-3, and then confirmed for the let7-a and miRcxcr4 miRNAs paired with artificially constructed mRNA targets.

Figure 1. In an actively dividing cell, miRNA binds to a complementary sequence in the 3′ untranslated region of mRNA and inhibits protein synthesis (translation).

However, in a resting cell, the same event leads to exactly the opposite effect. Interestingly, the effect of the same miRNA depended on the state of the cells: in dividing cells, miRNA suppressed mRNA translation, and in quiescent cells (temporarily left the cell cycle), on the contrary, it stimulated (Fig. 1). It is also interesting that miRNAs acted as part of a complex containing proteins Argonaute 2 And FXR1 Argonaute, and all of them deal with miRNA to one degree or another). It is these proteins that play the main role in the mechanism of the observed phenomenon, while miRNAs perform the function of a “replaceable adapter” through which proteins interact with various mRNA targets.

The question of the mechanism of action, as well as the avalanche of other, more specific questions raised by this publication, remain unanswered. But I remember the time when the phenomenon of RNA interference was just discovered - how clear everything was to us then and how logical it seemed!.. But now we can only shrug our shoulders - the further into the forest, the more firewood.

Literature

1. MicroRNAs were discovered for the first time in a single-celled organism;
2. Grigorovich S. (2003). Small RNAs in big science. Part 1. The phenomenon of small RNAs. scientific.ru;
3. J. R. Lytle, T. A. Yario, J. A. Steitz. (2007). Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5" UTR as in the 3" UTR. Proceedings of the National Academy of Sciences. 104 , 9667-9672;
4. S. Vasudevan, Y. Tong, J. A. Steitz. (2007). Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation. Science. 318 , 1931-1934;
5. Nicole Rusk. (2008). When microRNAs activate translation. Nat Methods. 5 , 122-123.